Randomised trials register

But this leaves untackled the large amount of unpublished trials. Rather than treat the problem of hidden research retrospectively, a more sensible approach might be to prevent it. While this is widely agreed to be a good approach, widespread registration has not yet been effected….

Who will take the lead? Apart from the NHS national research register and the Cochrane controlled trials register, the most significant recent lead has been taken by the pharmaceutical industry. For example, Schering Health Care and GlaxoWellcome have committed themselves to registering information about their own trials.

But how can this be so when all that GlaxoWellcome is doing is releasing administrative information about continuing work objective of the trial, end points, numbers, groups, and expected data of closure , not the actual data? Editors also have a part to play. During peer review, editors increasingly find themselves requesting copies of the original trial protocol to check against the final submitted report.

Publishers could also help this process by collaborating with one another to construct such a free online database. The lead here has been taken by Current Science , which launched a metaregister of randomised controlled trials in October Trials depend on patient participation and are often funded with public money.

Publishers make money from reprints of clinical trials, so it is reasonable to expect them to contribute to an initiative from which they ultimately benefit. A valuable partner might be PubMed Central, a project launched by director of the National Institutes of Health to create a free electronic archive of biomedical research. The pressure to register trials will rise when research ethics committees, medical research charities, and drug and device manufacturers start to encourage trialists to register, especially since the responsibility for not publishing trial results seems to rest more with investigators than editors.

One such scheme is being piloted in cancer, with the help of the Cochrane cancer network. Taken together, these efforts might bring shape to a presently formless clinical research enterprise. Such a structure should help to deliver high quality evidence to the clinical setting.

A version of this editorial also appears in the Lancet this week. National Center for Biotechnology Information , U. Studies should ideally be registered prospectively before recruitment starts.

Register your study Update your record Report your results. A prospective, single-center, clinical study to evaluate the efficacy and safety of silhouette soft suture as a treatment of nasolabial folds and jowl laxity.

Effects of dronabinol on dyspnea and quality of life in patients with chronic obstructive pulmonary disease: a randomized cross-over trial. For these items you should use the filters and not add them to your search terms in the text field. Download Options Subscribe to this Search. Displaying page 1 of Klinik f. Innere Medizin II, Abteilung f. A randomized double-blind controlled multicenter pilot study. This will provide an RSS feed for clinical trials matching your search that have been added or updated in the last 7 days.

Query did not match any studies. The status of studies in GB is no longer updated from 1. EU Clinical Trials Register. Search tools. Select Date Range: to. Select Rare Disease:. IMP with orphan designation in the indication. Orphan Designation Number:. Results Status: Trials with results Trials without results. Clear advanced search filters. EudraCT Number: Full Title: Styrian Vitamin D Hypertension Trial: A randomized, double-blind, placebo controlled trial to study the effects of vitamin D supplementation on systolic blood pressure in vitamin D deficient hypert Medical condition: Patients with arterial hypertension and vitamin D deficiency.

Trial protocol: AT Completed.