Devlin biochemistry with clinical correlations pdf

Devlin January A comprehensive and fully updated edition filled with over clinical correlations. This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease.

The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this seventh edition is an indispensable tool for students and professionals in the medical or health sciences.

This is a magnificent text: large, comprehensive, up-to-date These first 20 chapters constitute an essentially complete and exciting. As a multi-author treatise it does suffer some- biochemistry text.

However there are an additional six chap- what from variability of style, but overall Dr Devlin is to be ters covering some aspects of physiological chemistry: the commended as editor for the uniformity of quality and metabolism of individual tissues, iron and heme metabolism, point of view in this book.

These chapters vary considerably in biochemical has many things to commend it. Human biochemistry is content. There is little new here, of human systems. The 'Clinical Correlations', brief, boxed but it is convenient. On the other hand there is much new descriptions of biochemical events in pathological states, biochemistry in the chapter on iron and heme metabolism. And much of it will, after all, a chapter on ceils in this case eukaryotic only and cell com- appear in other required coursework of the medical or biology position, including a discussion on water and electrolytes.

Chapters on amino acids and protein structure, physiological The editor suggests that this book could serve as an upper proteins, enzymes, and membranes then follow. The first five division or graduate-level biochemistry text. For students chapters thus lay out the overall structural and functional in these courses the book has some advantages and some major aspects of biochemical systems.

An orientation towards deficiencies. To me the major advantages are its clear present- clinical biochemistry in these chapters is obvious in the selec- ation of the biochemistry of a single organism, particularly tion of examples the pH values of human fluids, electro- regulation and control, and the constant attention to correl- phoresis of serum proteins, ion exchange chromatography of ating particular pathways to specific tissues.

I feel that most hemoglobin, chromatographic finger-prints of Hb digests, students are better served by gaining an integrated under- isozyme assays etc and the proteins chosen for detailed standing of the workings of a single complete system, than examination hemoglobin, immunoglobulins, serum lipopro- they are by being inundated by scattered facts dealing with a teins. This orientation, along with the brief descriptions of the myriad of organisms.

I also feel it is important for students to many techniques of biochemistry and the many figures illus- realize that tissues in eukaryotes are specialized, in bio- trating clinical data, should make these valuable reference chemistry as well as function, and that biochemical integration chapters for the Medical Student. And it should motivate these often comes only at the whole organism level. I was also students with the obvious value of this material. How often in chapters each on carbohydrates, lipids and amino acids; and a the past have we created fallacious models based on unrealistic single chapter each on purines and pyrimidines, and on meta- in vitro experiments?

I really enjoyed these chapters. They The major deficiencies of this text are a complete lack of are rather light on detailed chemistry and enzyme mechanisms, plant biochemistry, including photosynthesis, and the various but they are excellent for metabolic regulation, pathway important pathways lacking in humans, such as essential amino localization and metabolic variations of tissues.

The consistent acid biosynthesis and vitamin biosynthesis. For the non- discussion of regulation in a single organism, man, is truly a medical student this is important stuff. Most students, includ- strong point. Many texts present regulatory features from a ing medical students, would also benefit from problems at the variety of organisms, which I often find confusing and even ends of the chapters. If you are studying towards a biochemistry degree, the realities are that you are definitely going to need many of the best biochemistry textbooks from well known authors, which will help you stay abreast of the research finding and theories in your studies and career.

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